Orthopaedic surgeons offer novel device trials to preserve joints in patients with early arthritis
Orthopaedic surgeons at Brigham and Women’s Hospital are studying numerous devices to help prevent or delay the need for joint replacement and expand treatment options for patients with early arthritis. In the ATLAS trial (below) they were the first in the United States to implant a new system that reduces joint load without altering anatomy in patients with medial knee osteoarthritis.
“There remains a significant treatment gap between the interventions that we can provide for the mild changes seen in early arthritis and arthroplasty for late-stage arthritis,” said Dr. Andreas Gomoll, an orthopaedic surgeon in the Department of Orthopaedic Surgery at BWH and Brigham and Women’s Faulkner Hospital. “We are seeing an increasing number of patients with early arthritis who are ineligible or fail these early interventions but are too young and active for knee replacement.”
ATLAS (Prospective, Multi-Center, Single Arm, Pilot Study to Evaluate Symptom Relief in Subjects With Medial Knee Osteoarthritis Treated With the Atlas™ Knee System for Load Reduction) – Orthopaedic surgeons at BWH were the first in the United States to implant this device, which is designed to treat knee osteoarthritis by absorbing excess load placed on the joint. The primary objective of this multicenter pilot study is to collect data on the safety and effectiveness of the Atlas Knee System in subjects with medial knee osteoarthritis through 24 months postoperative follow-up. There are no weight bearing restrictions during recovery, and the device does not alter the anatomy of the knee – enabling future surgical treatments as needed. Eligible patients include adults 25 to 80 years-of-age, with a diagnosis of medial knee osteoarthritis (Kellgen and Lawrence Grades 1-4, except those with bony erosions) and pain in the study knee (demonstrated as an overall WOMAC pain score of ≥40 on a scale of 0-100). For more information, or to refer a patient for this trial, please contact Amy Phan, Clinical Research Coordinator, at firstname.lastname@example.org.
VENUS (Verifying the Effectiveness of the NUsurface® System) – This multicenter, prospective randomized, interventional clinical trial is evaluating the safety and effectiveness of the NUsurface device compared to standard of care. The device is designed to produce better distribution of contact pressures within the knee joint, reducing joint overload and pain. Eligible patients include adults 30 to 75 years of age with medial compartment pain that have had previous partial medial meniscectomy within the past six months. The Knee Injury and Osteoarthritis Outcome Score (KOOS) and International Knee Documentation Committee (IKDC) forms will be used to provide a comprehensive evaluation of the patients’ pre-intervention and post-intervention condition, including activity levels, pain, swelling, locking, stability, support, sports activity and quality of life assessment. For more information, or to refer a patient for this trial, please contact Amy Phan, Clinical Research Coordinator, at email@example.com.
Additional Studies – Orthopaedic surgeons at BWH will be introducing several new studies in early 2017, including:
• The use of injectible medications for nonsurgical pain relief and potential structural improvement in patients with early knee arthritis.
• A preclinical study using stem cells to treat Achilles tendonitis.
To learn more or to refer a patient, please call our referral coordinators at 617-732-9894.